KRK
  • KRK
  • Veteran Member
3 years ago
In the not so great news department.....
https://www.medpagetoday.com/infectiousdisease/covid19/88234?xid=NL_breakingnewsalert_2020-08-24&eun=g430804d0r 

This has negative ramifications for vaccines as well.....a great therapeutic is typically better than vaccine. I just wish the silver bullet existed.
In Luce tua Videmus Lucem KRK
Cheesey
3 years ago

. I just wish the silver bullet existed.

Originally Posted by: KRK 



It does.....but it would only work if you wanted to kill a werewolf that had covid.
šŸ˜œ
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KRK
  • KRK
  • Veteran Member
3 years ago
Worth the 10 minute listen especially if you or someone you love is high risk
https://twitter.com/i/status/1297715098795094017 

In Luce tua Videmus Lucem KRK
KRK
  • KRK
  • Veteran Member
3 years ago
Interesting

Fauci on 'Highly Specific, Direct' Therapy for COVID-19
ā€” Can monoclonal antibodies duplicate the success with Ebola in COVID-19?

by Molly Walker, Associate Editor, MedPage Today
August 28, 2020


"There's a lot of activity and it's a highly concentrated, highly specific, direct antiviral approach to a number of diseases. The success in Ebola was very encouraging," said National Institute of Allergy and Infectious Diseases (NIAID) Director Anthony Fauci, MD.

Most recently thrust into the spotlight as effective treatments for Ebola, monoclonal antibodies are currently being researched as a potential treatment for HIV, as well as COVID-19. This month, the NIH highlighted trials of monoclonal antibodies being conducted among several different COVID-19 patient populations: outpatients with COVID-19, patients hospitalized with the disease, and even a trial in household contacts of confirmed cases, where the therapy was used as prophylaxis.

Fauci explained how the mechanism of monoclonal antibodies "is really one of a direct antiviral."

"It's like getting a neutralizing antibody that's highly, highly concentrated and highly, highly specific. So, the mechanism involved is blocking of the virus from essentially entering its target cell in the body and essentially interrupting the course of infection," he said.

While Fauci noted the success of monoclonal antibodies to treat Ebola, he added that they are not practical for other viruses that only last a day or two, where the virus may already be cleared once the patient receives the treatment."If you have a disease that's serious enough and prolonged enough, such as what we saw with Ebola, and what we are currently seeing with COVID-19, then you have enough opportunities to get the monoclonal antibody to actually work," he added.

Monoclonal antibodies are currently being administered intravenously, though Fauci said if the treatment works, "you try to get it to a form where you can give it subcutaneously or intramuscularly," a much more convenient way of administering the therapy.

He also explained the difference between monoclonal antibodies and convalescent plasma, describing them as "extremely pure," due to their homogeneous nature. Therefore the recent published side effects seen in trials of convalescent plasma in COVID-19 patients may not apply.

"The difference between monoclonal antibodies and convalescent plasma is plasma has a lot of other things in it, which could lead to allergic and other reactions," Fauci said. "Theoretically, there are more complex factors in plasma than there are with a monoclonal antibody."

Ultimately, when asked if one of his patients asked him about monoclonal antibodies, Fauci said he would say they are a "promising form of therapy."
"Many of them are still in clinical trials and not available for routine use, but the data that has accumulated recently indicates they are a very promising form of prevention and treatment," he noted


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Zero2Cool
3 years ago
Oh come on. Some positive tests don't have the virus?

I gotta read this one again later.

https://www.nytimes.com/2020/08/29/health/coronavirus-testing.html 
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Zero2Cool
3 years ago
Say what??



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KRK
  • KRK
  • Veteran Member
3 years ago
Wait.....what are you saying.....that the government would mislead us?

ā€œIt's easier to fool people than to convince them that they have been fooled.ā€ attributed to Mark Twain
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Zero2Cool
3 years ago
If you're interested, here's the report from CDC  that seems to have people in a raucous.

"For 6% of the deaths, COVID-19 was the only cause mentioned."
 image.png You have insufficient rights to see the content.

CDC changed how they display everything and now the positive tests number took a major jump. But it looks like the death rate is going down.
 image.png You have insufficient rights to see the content.

The column on the far right shows that age group plus the older age groups. So, 45-54 years and older account for 97.02% of the COVID-19 related deaths.
 image.png You have insufficient rights to see the content.

Just Wisconsin. 8 Males and 13 Females are not accounted for in this chart because they did not have their age available or did not provide it or ... no idea.
 image.png You have insufficient rights to see the content.
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KRK
  • KRK
  • Veteran Member
3 years ago
Could Boosting Vitamin D Cut COVID-19 Risk?
ā€” Observational study suggests there may be a link between the two
by Molly Walker, Associate Editor, MedPage Today September 3, 2020

Patients with "likely deficient" vitamin D status had nearly doubled risk of testing positive for COVID-19 versus those with "likely sufficient" vitamin D, a single-center study found.

Among nearly 500 patients, the relative risk for infection was 1.77 (95% CI 1.12-2.81, P=0.02) in those judged to be vitamin D-deficient (below 20 ng/mL or 18 pg/mL, respectively) compared with patients believed to have sufficient vitamin D, reported David Meltzer, MD, PhD, of the University of Chicago, and colleagues writing in JAMA Network Open.

Deficiency and sufficiency were estimated not only on the basis of vitamin D metabolite levels (25-hydroxycholecalciferol and 1,25-dihydroxycholecalciferol with thresholds of 20 ng/dL and 18 pg/mL, respectively) but also on records of vitamin D supplement prescriptions following those measurements.

The authors acknowledged one major caveat, however: vitamin D deficiency may be associated with many other COVID-19 risk factors, including age, obesity, diabetes, and chronic illness. Their statistical analysis included adjustments for many of these, but potential remained for residual confounding.

"[O]bserved associations of vitamin D with outcomes in almost any observational study may fail to accurately reflect any potential causal effects of vitamin D on outcomes," they cautioned.

The authors pointed to prior research suggesting a link between vitamin D and a decrease in other viral respiratory infections, and also noted vitamin D deficiency is "common." In particular, they cited the potential of shelter-in-place orders to decrease sun exposure, augmenting the need for vitamin D supplementation.

"To our knowledge, this study provides the first assessment of the association of vitamin D deficiency and potentially insufficient treatment with testing positive for COVID-19," they wrote.

Meltzer and colleagues drew on electronic health record data from 4,314 patients tested for COVID-19 at their institution from March 3 to April 10. Of these, 489 had complete data and were included in the sample. Average patient age was 49, 75% were women, and almost 70% were nonwhite (primarily Black).

One-quarter were determined to be likely deficient in vitamin D and 59% were likely sufficient; the remainder didn't qualify for either status because supplement prescriptions after measurement introduced uncertainty.

Compared to patients who weren't vitamin D deficient, those who were tended to be younger, a race other than white, more likely to receive vitamin D2 and less likely to receive vitamin D3.

Overall, 71 participants tested positive for COVID-19.

Other than vitamin D deficiency being a consequence of chronic health conditions or behavioral factors that increase COVID-19 risk, limitations to the data also include its limited sample size and that researchers were limited to data within the electronic health record.

Meltzer and colleagues suggested that interventions to reduce vitamin D deficiency, as a means to reduce COVID-19 risk, be tested in randomized trials. Such research would be especially pertinent since both African-American and Hispanic populations not only have disproportionate morbidity and mortality from COVID-19, but also high rates of vitamin D deficiency.
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Zero2Cool
3 years ago
Lovely, just freaking lovely. My youngest is now gonna have to be home schooled and we don't have any parent who can stay home from work to help her.
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