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  • KRK
  • Veteran Member

Fauci on 'Highly Specific, Direct' Therapy for COVID-19
— Can monoclonal antibodies duplicate the success with Ebola in COVID-19?

by Molly Walker, Associate Editor, MedPage Today
August 28, 2020

"There's a lot of activity and it's a highly concentrated, highly specific, direct antiviral approach to a number of diseases. The success in Ebola was very encouraging," said National Institute of Allergy and Infectious Diseases (NIAID) Director Anthony Fauci, MD.

Most recently thrust into the spotlight as effective treatments for Ebola, monoclonal antibodies are currently being researched as a potential treatment for HIV, as well as COVID-19. This month, the NIH highlighted trials of monoclonal antibodies being conducted among several different COVID-19 patient populations: outpatients with COVID-19, patients hospitalized with the disease, and even a trial in household contacts of confirmed cases, where the therapy was used as prophylaxis.

Fauci explained how the mechanism of monoclonal antibodies "is really one of a direct antiviral."

"It's like getting a neutralizing antibody that's highly, highly concentrated and highly, highly specific. So, the mechanism involved is blocking of the virus from essentially entering its target cell in the body and essentially interrupting the course of infection," he said.

While Fauci noted the success of monoclonal antibodies to treat Ebola, he added that they are not practical for other viruses that only last a day or two, where the virus may already be cleared once the patient receives the treatment."If you have a disease that's serious enough and prolonged enough, such as what we saw with Ebola, and what we are currently seeing with COVID-19, then you have enough opportunities to get the monoclonal antibody to actually work," he added.

Monoclonal antibodies are currently being administered intravenously, though Fauci said if the treatment works, "you try to get it to a form where you can give it subcutaneously or intramuscularly," a much more convenient way of administering the therapy.

He also explained the difference between monoclonal antibodies and convalescent plasma, describing them as "extremely pure," due to their homogeneous nature. Therefore the recent published side effects seen in trials of convalescent plasma in COVID-19 patients may not apply.

"The difference between monoclonal antibodies and convalescent plasma is plasma has a lot of other things in it, which could lead to allergic and other reactions," Fauci said. "Theoretically, there are more complex factors in plasma than there are with a monoclonal antibody."

Ultimately, when asked if one of his patients asked him about monoclonal antibodies, Fauci said he would say they are a "promising form of therapy."
"Many of them are still in clinical trials and not available for routine use, but the data that has accumulated recently indicates they are a very promising form of prevention and treatment," he noted

Oh come on. Some positive tests don't have the virus?

I gotta read this one again later.

  • KRK
  • Veteran Member
Wait.....what are you saying.....that the government would mislead us?

“It's easier to fool people than to convince them that they have been fooled.” attributed to Mark Twain
If you're interested, here's the report from CDC  that seems to have people in a raucous.

"For 6% of the deaths, COVID-19 was the only cause mentioned."
 image.png You have insufficient rights to see the content.

CDC changed how they display everything and now the positive tests number took a major jump. But it looks like the death rate is going down.
 image.png You have insufficient rights to see the content.

The column on the far right shows that age group plus the older age groups. So, 45-54 years and older account for 97.02% of the COVID-19 related deaths.
 image.png You have insufficient rights to see the content.

Just Wisconsin. 8 Males and 13 Females are not accounted for in this chart because they did not have their age available or did not provide it or ... no idea.
 image.png You have insufficient rights to see the content.
  • KRK
  • Veteran Member
Could Boosting Vitamin D Cut COVID-19 Risk?
— Observational study suggests there may be a link between the two
by Molly Walker, Associate Editor, MedPage Today September 3, 2020

Patients with "likely deficient" vitamin D status had nearly doubled risk of testing positive for COVID-19 versus those with "likely sufficient" vitamin D, a single-center study found.

Among nearly 500 patients, the relative risk for infection was 1.77 (95% CI 1.12-2.81, P=0.02) in those judged to be vitamin D-deficient (below 20 ng/mL or 18 pg/mL, respectively) compared with patients believed to have sufficient vitamin D, reported David Meltzer, MD, PhD, of the University of Chicago, and colleagues writing in JAMA Network Open.

Deficiency and sufficiency were estimated not only on the basis of vitamin D metabolite levels (25-hydroxycholecalciferol and 1,25-dihydroxycholecalciferol with thresholds of 20 ng/dL and 18 pg/mL, respectively) but also on records of vitamin D supplement prescriptions following those measurements.

The authors acknowledged one major caveat, however: vitamin D deficiency may be associated with many other COVID-19 risk factors, including age, obesity, diabetes, and chronic illness. Their statistical analysis included adjustments for many of these, but potential remained for residual confounding.

"[O]bserved associations of vitamin D with outcomes in almost any observational study may fail to accurately reflect any potential causal effects of vitamin D on outcomes," they cautioned.

The authors pointed to prior research suggesting a link between vitamin D and a decrease in other viral respiratory infections, and also noted vitamin D deficiency is "common." In particular, they cited the potential of shelter-in-place orders to decrease sun exposure, augmenting the need for vitamin D supplementation.

"To our knowledge, this study provides the first assessment of the association of vitamin D deficiency and potentially insufficient treatment with testing positive for COVID-19," they wrote.

Meltzer and colleagues drew on electronic health record data from 4,314 patients tested for COVID-19 at their institution from March 3 to April 10. Of these, 489 had complete data and were included in the sample. Average patient age was 49, 75% were women, and almost 70% were nonwhite (primarily Black).

One-quarter were determined to be likely deficient in vitamin D and 59% were likely sufficient; the remainder didn't qualify for either status because supplement prescriptions after measurement introduced uncertainty.

Compared to patients who weren't vitamin D deficient, those who were tended to be younger, a race other than white, more likely to receive vitamin D2 and less likely to receive vitamin D3.

Overall, 71 participants tested positive for COVID-19.

Other than vitamin D deficiency being a consequence of chronic health conditions or behavioral factors that increase COVID-19 risk, limitations to the data also include its limited sample size and that researchers were limited to data within the electronic health record.

Meltzer and colleagues suggested that interventions to reduce vitamin D deficiency, as a means to reduce COVID-19 risk, be tested in randomized trials. Such research would be especially pertinent since both African-American and Hispanic populations not only have disproportionate morbidity and mortality from COVID-19, but also high rates of vitamin D deficiency.
Lovely, just freaking lovely. My youngest is now gonna have to be home schooled and we don't have any parent who can stay home from work to help her.
  • KRK
  • Veteran Member
And this is why we are closing schools?!?!?!?...hmmmm, why do you think that is ??? There couldn't be any politics involved...could there!?!?!?

Don't worry Z2C, schools will be open the day after the election.

 CDC Data.jpg You have insufficient rights to see the content.


*The best estimate representative of the point estimates of R0 from the following sources:
Chinazzi M, Davis JT, Ajelli M, et al. The effect of travel restrictions on the spread of the 2019 novel coronavirus (COVID-19) outbreak. Science. 2020;368(6489):395-400; Imai N., Cori, A., Dorigatti, I., Baguelin, M., Donnelly, C. A., Riley, S., Ferguson, N.M. (2020). Report 3: Transmissibility of 2019-nCoV. Online report
Li Q, Guan X, Wu P, et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med. 2020;382(13):1199-1207
Munayco CV, Tariq A, Rothenberg R, et al. Early transmission dynamics of COVID-19 in a southern hemisphere setting: Lima-Peru: February 29th-March 30th, 2020 [published online ahead of print, 2020 May 12]. Infect Dis Model. 2020; 5:338-345
Salje H, Tran Kiem C, Lefrancq N, et al. Estimating the burden of SARS-CoV-2 in France [published online ahead of print, 2020 May 13] [published correction appears in Science. 2020 Jun 26;368(6498):]. Science. 2020;eabc3517.
The range of estimates for Scenarios 1-4 represent the upper and lower bound of the widest confidence interval estimates reported in: Li Q, Guan X, Wu P, et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med. 2020;382(13):1199-1207.
Substantial uncertainty remains around the R0 estimate. Notably, Sanche S, Lin YT, Xu C, Romero-Severson E, Hengartner N, Ke R. High Contagiousness and Rapid Spread of Severe Acute Respiratory Syndrome Coronavirus 2. Emerg Infect Dis. 2020;26(7):1470-1477 (https://dx.doi.org/10.3201/eid2607.200282external icon) estimated a median R0 value of 5.7 in Wuhan, China. In an analysis of 8 Europe countries and the US, the same group estimated R0 of between 4.0 and 7.1 in the pre-print manuscript: Ke R., Sanche S., Romero-Severson, & E., Hengartner, N. (2020). Fast spread of COVID-19 in Europe and the US suggests the necessity of early, strong and comprehensive interventions. medRxiv.
Originally Posted by: KRK 

And this is why we are closing schools?!?!?!?...hmmmm, why do you think that is ??? There couldn't be any politics involved...could there!?!?!?

Don't worry Z2C, schools will be open the day after the election.

I'm sure there are politics involved. And if we didn't have Social Media, I'm willing to bet the political side of it wouldn't be nearly as impactful. As for schools opening up the day after the election, I doubt that. I think there are going to be so many write-ins or absentee ballets (whatever they are called) that it'll take weeks, if not over a month to decide who won the election.

I really am hating the loud squeaky wheel crowd. I'm trying to be open minded, but it's just not working. I'm getting filled with anger more and more everyday over this.
  • KRK
  • Veteran Member
Also, as a follow-up to the HCQ discussions... image.png You have insufficient rights to see the content.

Many countries either adopted or declined early treatment with HCQ, effectively forming a large trial with 1.8 billion people in the treatment group and 663 million in the control group. As of September 20, 2020, an average of 70.1 per million in the treatment group have died, and 477.2 per million in the control group, relative risk 0.147. After adjustments, treatment and control deaths become 146.8 per million and 715.0 per million, relative risk 0.21. The probability of an equal or lower relative risk occurring from random group assignments is 0.015. Accounting for predicted changes in spread, we estimate a relative risk of 0.26. The treatment group has a 73.9% lower death rate. Confounding factors affect this estimate. We examined diabetes, obesity, hypertension, life expectancy, population density, urbanization, testing level, and intervention level, which do not account for the effect observed.
That’s the problem. The election should be over and decided by the day after.
If you don’t get your ballot in by 8pm Election Day, it should not count.
Laziness shouldn’t be an excuse.
I and my wife already took care of it. There’s no excuse for people not to get it done.
And the virus is being used by the Democrats to blame the President like somehow it’s his fault.
Like I said before, Trump was called a racist when he shut down incoming flights from China. Then they scream he didn’t act fast enough.
Which is it?
I know....which ever they can try to use against him at the time.
I’m sure that right after the election, a lot of the virus problems will disappear. (At least in the “official numbers”) unless of course Trump wins re-election.
UW La Crosse just cancelled spring break. As a parent of a pretty little blond girl, I'm good with this! I don't need my kid trying to do Girls Gone Wild kinda shit!!!

Here's some alleged Masks facts.
Originally Posted by: Zero2Cool 

UW La Crosse just cancelled spring break. As a parent of a pretty little blond girl, I'm good with this! I don't need my kid trying to do Girls Gone Wild kinda shit!!!

Here's some alleged Masks facts.

So....how does Dad know about “Girls Gone Wild”???🤪😂
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Zero2Cool (11h) : Allen Lazard will return to practice this week, coach Matt LaFleur just said.
Zero2Cool (12h) : Packers are among the teams to inquire about #Texans WR Will Fuller, according to a league source, but no deal imminent.
Zero2Cool (12h) : AP source: Seahawks land DE Carlos Dunlap from Cincinnati.
Cheesey (13h) : The way it’s going, the Big10 champions will be which ever team is still healthy at the end of the season.
Zero2Cool (13h) : Breaking: The Wisconsin football team will pause all team-related activities for at least seven days due to an elevated number of COVID-19 cases within the Badgers program.
Zero2Cool (14h) : Texans will be closing their facility due to a player testing positive for COVID-19, source said. They are on a bye week now. They are testing all other players.
beast (16h) : As long as they have excuses, MM will stay at least 3 years... they refused to let the prior guy go until his contract was up. Cowboys need more defensive talent and they got no cap space.
Zero2Cool (17h) : Someone might be traded, lol. Report: Bengals tell Carlos Dunlap to stay home Wednesday
Cheesey (28-Oct) : The Cowboys stunk WITH Dak as QB. But maybe J.Jones will give MM another year before he cans him.
Smokey (28-Oct) : An Ohh S--T, decision !
Smokey (28-Oct) : 100% Agree
TheKanataThrilla (28-Oct) : Tampa GM is stupid
TheKanataThrilla (28-Oct) : I hope they win, but sorry Tampa I think pulling Snell is stupid at this point.
TheKanataThrilla (28-Oct) : Does the current QB injury situation save Mike McCarthy from being fired?
Zero2Cool (28-Oct) : Oh, my bad. Dallas Cowboys traded him. Oops
Zero2Cool (28-Oct) : Vikings traded Everseon Griffen to Lions.
Zero2Cool (28-Oct) : Panthers release CB Josh Hawkins after he was seen dancing in public without a mask
Zero2Cool (27-Oct) : Dolphins are exploring trade offers for CB Xavien Howard, per @OmarKelly. They have an offer on the table and are seriously considering moving him before next week's deadline. Howard signed a large 5-
Zero2Cool (27-Oct) : Badgers QB Graham Mertz positive test *confirmed* for COVID-19. He'll miss 21 days.
Zero2Cool (27-Oct) : Why we go up, and down all the time?
Cheesey (27-Oct) : Thanks for the info Wayne!
Zero2Cool (27-Oct) : Wisconsin is potentially down to its fourth string quarterback for the next 21 days because of overly restrictive Big Ten policies on positive covid test results
wpr (27-Oct) : Cheesey, not really. If he was good he wouldn't have been released. He has never had 500 yards in a season. In his best year he caught 45 passes out of 64 targets..
Cheesey (27-Oct) : I don’t know anything about him. Is he any good?
Zero2Cool (27-Oct) : From Twitter... Packers are bringing in veteran WR Seth Roberts, who was released by the Panthers earlier today. A source said the plan is to sign him to the practice squad initially.
Smokey (26-Oct) : Fred & Ethel Mertz used be "Lucey & Rickey's" neighbors on the I Love Lucey show. Is this fellow related ? LOL
Zero2Cool (26-Oct) : @Gil_Brandt Davante Adams has two games this season of 150+ receiving yards and 2+ receiving touchdowns. The rest of the NFL's receivers has two such games in 2020 (Justin Jefferson and Tyler Lockett)
Cheesey (26-Oct) : Mertz, the Wisconsin Badgers QB.
Zero2Cool (26-Oct) : Terrible. @JosinaAnderson Odell Beckham Jr just text me that his ACL is torn and that his season is over.
Smokey (26-Oct) : Who?
Zero2Cool (26-Oct) : Graham Mertz, who had a record-setting first career start Friday, tested positive for COVID-19
yooperfan (26-Oct) : Thanks WPR, I had never heard his name before.
Mucky Tundra (26-Oct) : What is it with Seattle and close games?
wpr (26-Oct) : Yoop Black is a PS player called up for the game.They sent him back down already. I hope Amos gives him the ball b/c that may be his only game trophy.
KRK (26-Oct) : T/F after the game, 12 was talking to Ken Stills for 5 minutes. Trade for Stills?
yooperfan (25-Oct) : Who the hell is Henry Black?
Cheesey (25-Oct) : I agree Zero. Helmet to helmet as he was sliding.
Zero2Cool (25-Oct) : Terrible hit on Andy Dalton.
Cheesey (25-Oct) : Wow Yoop! I didn’t think you were that much older then me.
Zero2Cool (25-Oct) : Inactives : 32 RB Tyler Ervin 33 RB Aaron Jones 69 T David Bakhtiari 10 QB Jordan Love 20 CB Kevin King 95 DL Tyler Lancaster 26 S Darnell Savage
Zero2Cool (25-Oct) : Official. Damn it! Aaron Jones— OUT today for GB.
yooperfan (25-Oct) : Cheesey I’m going on 73.
Zero2Cool (25-Oct) : Ego has no amigo
Zero2Cool (25-Oct) : NFL fined the #Titans $350,000 for violating COVID-19 protocols. League won’t hand out individual fines or strip draft picks. Case closed.
Mucky Tundra (25-Oct) : Holy crap what a crazy ending to a World Series game!
Zero2Cool (25-Oct) : We'll see about Jones. Packers are leaning on holding him, but it's game time decision.
packerfanoutwest (25-Oct) : Jones is out for the game with a calf strain
packerfanoutwest (25-Oct) : Jones is out for the game with a calf strain
Cheesey (25-Oct) : Not surprised about Bak. I think the Packers knew all along he wasn’t going to play.
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